Bioinformatics and Functional Genomics 3rd Edition

Chapter 19: The Eukaryotic Genome

We continue to explore the genomes of all life forms using the tools of bioinformatics. Following our introduction using fungi in the previous chapter we now arrive at the eukaryotes, from parasites to plants to primates. This page offers web documents and resources that are referred to in Chapter 19. Figure 19.1 presents a tree by Baldauf et al. showing the relationships of the eukaryotes, and in the chapter we follow this tree from bottom up. Topics include the protozoans (Trichomonas, Giardia); unicellular pathogens (trypanosomes and Leishmania); the Chromalveolates (the malaria parasite P. falciparum and other apicomplexans; the ciliophora Paramecium and Tetrahymena; nucleomorphs; Stramenopiles such as diatoms); the plants; and slime molds. When we arrive at the metazoans (animals) we divide these into the great groups of nematodes (such as the worm C. elegans), insects (e.g. fruitfly, mosquito, honeybee), and chordates (Ciona). We conclude with descriptions of fish (diverged from humans about 450 million years ago [MYA]), chickens (310 MYA), opposum (180 MYA), mammals from dog to cow (100 MYA), rodents (80 MYA), and primates (50-5 MYA). For each organism we survey its genome, highlighting key properties such as the number and nature of the chromosomes.