Ethics Program at Kennedy Krieger

Ethics Program at Kennedy Krieger

Ethics Program at Kennedy Krieger Institute

Helping with xxxx
decisions about care, treatment, and services

Kennedy Krieger Ethics Committee

Welcome to the Ethics Committee

Introduction

Down syndrome is the most common and readily identifiable chromosomal condition associated with mental retardation. It is a genetic disorder that occurs in approximately 1 in 800 live births. The disorder is caused most often by an abnormality during cell division in gamete formation called nondisjunction. As a result, the fertilized egg will contain three copies of chromosome 21. The extra chromosome interferes with normal growth and development. In most cases, the diagnosis of Down syndrome is made according to results from a chromosome test administered shortly after birth.

Down Syndrome

This site provides [1] information on Down syndrome, [2] raw data and supplementary information for Mao et al. (Genomics 2003 May, 81(5)) "Global up-regulation of chromosome 21 gene expression in the developing Down Syndrome brain" and [3] raw and supplementary data for Mao et al. (2005), "Role of gene expression in the developing human Down syndrome brain and heart."

Introduction What is Down Syndrome?
Approach Our approach to Down Syndrome
Links Down Syndrome links

kcoeff

Welcome

We have analyzed SNP data to define relatedness between individuals, including K0, K1, and K2 which are estimates of the Cotterman coefficients of relatedness k0, k1, and k2. This web page provides access to an executable to run kcoeff, a program that accepts SNP genotype data as input and calculates K0, K1, and K2.

We recommend using SNPduo++ to measure the IBS2*_ratio (IBS2*/[IBS2* + IBS0]):

Welcome To The Pevsner Laboratory

Welcome to the laboratory of Jonathan Pevsner. Our lab studies the genetic basis of childhood brain disorders. We are located at the Kennedy Krieger Institute in Baltimore.

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